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Recent Publications/Conference Presentations
Publications:
"A Novel b-Lactam Antibiotic Activates Tumor Cell Apoptotic Program by Inducing DNA Damage," David M. Smith, Aslamussaman Kazi, Lisa Smith, Timothy E. Long, Bart Heldreth, Edward Turos, and Q. Ping Dou, Molecular Pharmacology 61, 1348-1358 (2002).
"N-Thiolated b-Lactams," Timothy E. Long and Edward Turos, Current Medicinal Chemistry- Anti-Infective Agents 1, 251-268 (2002).
"N-Thiolated b-Lactams: Novel Antibacterial Agents for Methicillin-Resistant Staphylococcus Aureus," Edward Turos, Timothy E. Long, Monika I. Konaklieva, Cristina Coates, Jeung-Yeop Shim, Sonja Dickey, Daniel V. Lim, and Andrew Cannons, Bioorganic and Medicinal Chemistry Letters 12, 2229-2231 (2002).
"N-Thiolated b-Lactam Antibacterials: Defining the Role of Unsaturation in the C4 Side Chain," Cristina Coates, Timothy E. Long, Edward Turos, Sonja Dickey, and Daniel V. Lim, Bioorganic and Medicinal Chemistry 11, 193-196 (2003).
"Effect of Aryl Ring Fluorination on the Antibacterial Properties of C4 Aryl-Substituted N-Methylthio b-Lactams," Timothy E. Long, Edward Turos, Monika I. Konaklieva, Allison L. Blum, Amal Amry, Ejae A. Baker, Lita S. Suwandi, Melodie D. McCain, Miti F. Rahman, Sonja Dickey, and Daniel V. Lim, Bioorganic and Medicinal Chemistry 11, 1859-1863 (2003).
“Lipase-Catalyzed Resolution of Racemic Substituted 4-Aryl b-Lactams,” Jason A. Carr, Talal F. Al-Azemi, Timothyl E. Long, Jeung-Yeop Shim, Cristina A. Coates, Edward Turos, and Kirpal S. Bisht, Tetrahedron 59, 9147-9160 (2003).
“Novel N-Thiolated b-Lactam Antibiotics Selectively Induce Apoptosis in Human Leukemic, but Not Non-Transformed Natural Killer Cells and Inhibit the Transforming Activity of Prostate Cancer Cells,” Aslamuzzaman Kazi, Randy Hill, Timothy E. Long, Deborah J. Kuhn, Edward Turos, and Q. Ping Dou, Biochemical Pharmacology 67, 365-374 (2004).
"Beta-Lactams and Their Potential Use as Novel Anti-Cancer Chemotherapeutic Drugs,” Deborah Kuhn, Cristina Coates, Kenyon Daniel, Di Chen, Mohammad Bhuiyan, Edward Turos, and Q. Ping Dou, Frontiers in Bioscience, 9, 2605-2617 (2004).
“Structure-Activity Relationships of N-Methylthiolated b-Lactam Antibiotics with C3 Substitutions and Their Selective Induction of Apoptosis in Human Cancer Cells,” Deborah Kuhn, Yang Wang, Vesna Minic, Cristina Coates, G.. Suresh Kumar Reddy, Kenyon G.. Daniel, Jeung-Yeop Shim, Di Chen, Kristin R. Landis-Piwowar, Fred R. Miller, Edward Turos, and Q. Ping Dou, Frontiers in Bioscience 10, 1183-1190 (2005).
“Microbiological Properties and Modes of Action of Organosulfur-Based Anti-infectives,” Bart Heldreth and Edward Turos, Current Medicinal Chemistry- Anti-Infective Agents 4, 295-315 (2005).
“N-Methylthio b-Lactam Antibacterials: Effects of the C3/C4 Ring Substituents on Anti-MRSA Activity,” Edward Turos, Cristina Coates, Jeung-Yeop Shim, Yang Wang, J. Michelle Roettgers, Timothy E. Long, G. Suresh Kumar Reddy, Alex Ortiz, Marci Culbreath, Sonja Dickey, Daniel V. Lim, Eduardo Alonso and Javier Gonzalez, Bioorganic and Medicinal Chemistry 13, 6289-6308 (2005).
“b-Lactams,” Cristina Coates, Jasmine Kabir, and Edward Turos, Compounds with Four and Three Carbon-Heteroatom Bonds, Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Volume 21, Section 21.9, 609-646 (2005). “N-Thiolated 2-Oxazolidinones: A New Family of Antibacterial Agents for Methicillin-Resistant
Staphylococcus aureus (MRSA) and Bacillus anthracis,” Rajesh K. Mishra, Kevin D. Revell,
Cristina M. Coates, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry Letters 16,
2081-2083 (2006).
“N-Thiolated b-Lactams: A New Family of Anti-Bacillus Agents,” Edward Turos, Timothy E. Long,
Bart Heldreth, Jeanne M. Leslie, Suresh K.R. Guntireddygari, Yang Wang, Cristina Coates,
Monika Konaklieva, Sonja Dickey, Daniel V. Lim, Eduardo Alonso, Javier Gonzalez, Bioorganic and
Medicinal Chemistry Letters 16, 2084-2090 (2006).
“N-Thiolated b-Lactam Antibacterials: Effects of the N-Organothio Substituent on anti-MRSA
Activity,” Bart Heldreth, Timothy E. Long, Seyoung Jang, Suresh K.R. Guntireddygari, Edward
Turos, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry 14, 3775-3784 (2006).
“Antibiotic-Conjugated Polyacrylate Nanoparticles: New Opportunities for Development of Anti-MRSA Agents” Edward Turos, Jeung-Yeop Shim, Yang Wang, Kerriann Greenhalgh, G. Suresh Kumar Reddy, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry Letters 16, in press (2006).
"N-thiolated B-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus". Kevin D Revell, Bart Heldreth et al. Bioorganic and Medicinal Chemistry 15, 2453-2467 (2007).
Conferences:
“Emulsified Polymer Nanoparticles: Applications to New Drug Delivery Vehicles,” Edward Turos, Nano/Bio Convergence Conference 2004, Hyatt Regency Cambridge, Cambridge, MA, March 28-30, 2004.
“Emulsified Polymer Nanoparticles: Applications to New Drug Delivery Vehicles,” Jeung-Yeop Shim and Edward Turos, Florida Annual Meeting and Exposition, Orlando, FL, May 6, 2004”Antibacterially-Active Polyacrylate Nanospheres,” Helen Wang and Edward Turos, Florida Annual Meeting and Exposition, Orlando, FL, May 6, 2004.
“Sugar-Coated Nanoparticles,” Sampath Abeylath and Edward Turos, Florida Annual Meeting and Exposition, Orlando, FL, May 6, 2004.
“New Nanoparticle Drug Delivery Platforms,” Edward Turos, The 21st Annual International Technology Transfer Forum, Reston, VA, May 9-11, 2004.
“Emulsified Polymer Nanoparticles For Drug Delivery And Materials Research,” Edward Turos, 2nd Annual Symposium on Nanomedicine and Drug Delivery, Brooklyn Polytechnical Institute, New York City, NY, August 19-20, 2004.
"Sugar-Coated Nanobiotics", Sampath Abeylath and Edward Turos, Fifth Annual Raymond N. Castle Student Research Conference, University of South Florida, April 29, 2006.
"Surfactant_Free Nanoparticles for Delivery of Antibiotics," Julio Garay and Edward Turos, Fifth Annual Raymond N. Castle Student Research Conference, University of South Florida, April 29, 2006.
"Penicillin-bound Nanoparticles: A Potential Way to Overcome Drug Resistance in Bacteria,; Praveen Ramaraju and Edward Turos, Fifth Annual Raymond N. Castle Student Research Conference, University of South Florida, April 29, 2006.
"New Functionalized Caprolactone Polymers for Biomedical Uses," Michelle Leslie and Edward Turos, Florida Annual Meeting and Exposition, May 11, 2006, Orlando, FL.
"'Surfactant-Free' Nanoparticles for Delivery of Antibiotics," Julio Garay and Edward Turos, Florida Annual Meeting and Exposition, May 11, 2006, Orlando, FL.
"Antibiotic-Conjugated Sugar Bearing Polyacrylate Nanoparticles," Sampath Abeylath and Edward Turos, Florida Annual Meeting and Exposition, May 11, 2006, Orlando, FL.
"Penicillin-Bound Nanoparticles: A Potential Way to Overcome Drug-Resistance in Bacteria," Praveen Ramaraju and Edward Turos, Florida Annual Meeting and Exposition, May 11, 2006, Orlando, FL.
"Inhibition of Type II Fatty Acid Synthesis by Small Aryl-Alkyl Disulfides: Mode of Action and SAR," Kevin Revell and Edward Turos, 58th Southeast Regional Meeting, November 1-4, 2006, Augusta, GA.
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